Takotsubo kardiomyopati symtom
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Takotsubo Syndrome - American College of Cardiology
NCBI Bookshelf. Sarah A. Authors Sarah A. Ibrahim 4. Takotsubo cardiomyopathy, also known as Gebrochenes-Herz syndrome, transient apical ballooning syndrome, apical ballooning cardiomyopathy, stress-induced cardiomyopathy, stress cardiomyopathy, and broken-heart syndrome, is a form of non-ischemic cardiomyopathy. It is characterized by transient regional systolic dysfunction of the left ventricle mimicking acute myocardial infarction but with only minimal release of cardiac enzymes.
There is a paucity of angiographic evidence of obstructive coronary artery disease or acute plaque rupture.
Takotsubo Cardiomyopathy: What to Know About ‘Broken Heart Syndrome’
In most cases of takotsubo cardiomyopathy, the regional wall motion abnormality extends beyond the territory perfused by a single epicardial coronary artery. The term takotsubo means octopus trap in Japanese. It has a shape that is similar to the systolic apical ballooning appearance of the left ventricle. This activity reviews takotsubo cardiomyopathy and highlights the interprofessional team's role in the recognition and management of patients affected by it.
Objectives: Describe exam findings consistent with takotsubo cardiomyopathy. Identify the testing that should be done if takotsubo cardiomyopathy is suspected. Explain management considerations for takotsubo cardiomyopathy.
Takotsubo cardiomyopathy: A comprehensive review - PMC
Summarize a well-coordinated interprofessional team approach to provide effective care to patients affected by takotsubo cardiomyopathy. Access free multiple choice questions on this topic. Takotsubo cardiomyopathy is also known as a transient apical ballooning syndrome, apical ballooning cardiomyopathy, stress-induced cardiomyopathy, stress cardiomyopathy, and Gebrochenes-Herz syndrome, and broken-heart syndrome is a form of non-ischemic cardiomyopathy and predominantly affects post-menopausal women.
In most takotsubo cardiomyopathy cases, the regional wall motion abnormality extends beyond the territory perfused by a single epicardial coronary artery. The term takotsubo is a Japanese name for an octopus trap. The exact etiology of takotsubo cardiomyopathy is not fully understood. Several mechanisms are hypothesized as possible etiologies of takotsubo cardiomyopathy, including sympathetic overdrive with increased catecholamines, coronary spasm, microvascular dysfunction, low estrogen levels, inflammation, or impaired myocardial fatty acid metabolism.
Risk factors for the development of takotsubo cardiomyopathy include domestic abuse, death of relatives, natural calamities, accident or major trauma, arguments, financial or gambling loss, diagnosis of an acute medical illness, stimulant drugs such as cocaine, amphetamines, or even positive life events the so-called' happy heart syndrome. The real incidence of takotsubo cardiomyopathy is uncertain.
Takotsubo Syndrome
In the International Takotsubo Registry study a consortium of multiple centers across Europe and America of patients , approximately The precise pathophysiologic mechanism underlying takotsubo cardiomyopathy remains elusive. Various hypotheses have been postulated and include elevated levels of circulating plasma catecholamines and their circulating metabolites due to underlying stress, microvascular dysfunction or microcirculatory disorder, inflammation, estrogen deficiency, spasm of the epicardial coronary vessels, and aborted myocardial infarction.
Catecholamines can cause microvascular spasms, dysfunction, myocardial stunning, or direct myocardial injury. Estrogen exerts protective effects on the cardiovascular system, including vasodilation, protection against atherosclerosis, and endothelial dysfunction. Therefore, post-menopausal women exhibit exaggerated vasoconstriction, altered endothelium-dependent vasodilatation, and sympathetic activation in response to psychosocial stress.
The role of inflammation in takotsubo cardiomyopathy is depicted by cardiac magnetic resonance imaging, which shows myocardial edema, necrosis, fibrosis, and late gadolinium enhancement. An impaired microvascular function has also been demonstrated by measuring the index of microvascular resistance by introducing a pressure wire in the coronary arteries. Endomyocardial biopsy of patients with takotsubo cardiomyopathy demonstrates reversible focal lysis of myocytes, mononuclear infiltrates, and contraction band necrosis.
Takotsubo cardiomyopathy presentation is similar to acute coronary syndrome.